三尖杉宁 A-C：来自中国三尖杉的三种新的石松烷型二萜。

Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

Org Lett. 2010 Mar 19;12(6):1168-71. doi: 10.1021/ol9028995.

DOI:10.1021/ol9028995

PMID:20148570

Abstract

Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Compound 3 showed significant inhibition against MET tyrosine kinase activity with a IC(50) value of 1.95 microM.

摘要

从黄桐中分离得到三种高度氧化的新二萜类化合物，即 trigochinins A-C（1-3）。通过光谱法、X 射线晶体学和 CD 分析确定了它们的结构和绝对构型。本研究建议对最近报道的 trigonothyrins A-C 的 C-6 立体化学进行修订。化合物 3 对 MET 酪氨酸激酶活性表现出显著的抑制作用，IC（50）值为 1.95 microM。