从三脉叶马兜铃中提取到具有高官能团化的瑞香烷二萜。

Highly functionalized daphnane diterpenoids from Trigonostemon thyrsoideum.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

Org Lett. 2010 Jan 1;12(1):152-5. doi: 10.1021/ol9025638.

DOI:10.1021/ol9025638

PMID:19968236

Abstract

Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 microg/mL, and the therapeutic index (TI) was more than 90.

摘要

三尖杉宁 A-C（1-3）是从三尖杉科三尖杉属植物中分离得到的高度官能化的紫衫烷二萜类化合物。化合物 1-3 代表了第一个具有氧桥四元环系统和 12,13,14-orthoester 连接方式的紫衫烷类化合物。化合物 3 被观察到抑制 HIV-1 诱导的细胞病变作用。EC(50)值为 2.19 μg/mL，治疗指数（TI）大于 90。