来自三脉叶马兜铃茎的瑞香烷二萜及其抗 HIV-1 活性。
Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
Phytochemistry. 2013 Sep;93:216-21. doi: 10.1016/j.phytochem.2013.03.003. Epub 2013 Apr 27.
Thirteen highly oxygenated daphnane diterpenoids, including six known compounds, were isolated from the stems of Trigonostemon lii. The structures were elucidated by extensive spectroscopic analyses including 2D NMR spectroscopy (HSQC, (1)H-(1)H COSY, HMBC, and ROESY) and mass spectrometry. The absolute stereochemistries of compounds were established on the basis of CD spectra. Four of the compounds showed modest anti-HIV-1 activity (EC50=2.04, 9.17, 11.42, and 9.05 μg/ml, TI=26.49, >21.81, 9.32, and 9.56, respectively) in vitro.
从李瑞桐的茎中分离得到了 13 种高度氧化的瑞香烷二萜，包括 6 种已知化合物。通过广泛的光谱分析，包括 2D NMR 光谱（HSQC、（1）H-（1）H COSY、HMBC 和 ROESY）和质谱，确定了这些化合物的结构。根据 CD 光谱确定了化合物的绝对立体化学。其中 4 种化合物表现出适度的抗 HIV-1 活性（EC50=2.04、9.17、11.42 和 9.05 μg/ml，TI=26.49、>21.81、9.32 和 9.56，分别）。
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