Lagos State University Teaching Hospital, Lagos, Nigeria.
Climacteric. 2011 Feb;14(1):75-82. doi: 10.3109/13697130903568526. Epub 2010 Feb 12.
To determine the frequency of occurrence of the metabolic syndrome and the age of onset and pattern of menopausal symptomatology in Nigerian women with type 2 diabetes mellitus.
This was a cross-sectional study in which 201 menopausal women with type 2 diabetes mellitus aged between 40 and 85 years were studied. Their anthropometric indices, fasting lipid values, glucose parameters, uric acid and HbA(1c) were documented. The presence of the metabolic syndrome and menopausal symptoms were determined using the National Cholesterol Panel-ATP definition and MENQOL questionnaire, respectively. The test statistics used included the t test, χ(2) and correlation coefficient.
The mean age (standard deviation) of the onset, median age and age range of menopause were 50.3 (4.8) years, 50 years and 40-57 years, respectively. The frequency of occurrence of menopausal symptoms ranged from 14% to 76%. Hot flushes, night sweats and dry skin are some of the vasomotor symptoms which occurred in 38%, 31% and 30%, respectively, of the subjects. The prevalence of the metabolic syndrome was 69%, with the pattern of occurrence of the menopausal symptoms being comparable in subjects with and without the metabolic syndrome. The frequency of occurrence of hyperuricemia in the study population was 42%. In the partial correlation analysis, serum uric acid concentration was significantly positively correlated with body mass index (r = 0.15, p = 0.02) and significantly negatively correlated with high density lipoprotein cholesterol (r = -0.1, p = 0.03).
The age of onset of menopause in Nigerian women with type 2 diabetes mellitus is comparable to the age that is commonly reported and the metabolic syndrome is highly prevalent in this group of women.
确定尼日利亚 2 型糖尿病女性代谢综合征的发生频率、发病年龄以及绝经症状模式。
这是一项横断面研究，共纳入 201 例年龄在 40-85 岁之间的 2 型糖尿病绝经女性。记录其人体测量学指标、空腹血脂值、血糖参数、尿酸和糖化血红蛋白（HbA(1c)）。采用国家胆固醇教育计划（NCEP）-ATP 定义和绝经质量问卷（MENQOL）分别确定代谢综合征和绝经症状的存在。使用的检验统计包括 t 检验、χ(2)检验和相关系数。
绝经年龄的平均年龄（标准差）、中位数年龄和年龄范围分别为 50.3（4.8）岁、50 岁和 40-57 岁。绝经症状的发生频率范围为 14%-76%。热潮红、盗汗和皮肤干燥是一些血管舒缩症状，分别在 38%、31%和 30%的受试者中发生。代谢综合征的患病率为 69%，有和无代谢综合征的受试者中绝经症状的发生模式相似。研究人群中高尿酸血症的发生率为 42%。在偏相关分析中，血清尿酸浓度与体重指数呈显著正相关（r=0.15，p=0.02），与高密度脂蛋白胆固醇呈显著负相关（r=-0.1，p=0.03）。
尼日利亚 2 型糖尿病女性的绝经年龄与通常报道的年龄相当，而该组女性代谢综合征的患病率很高。
