单剂量抗生素预防术后艰难梭菌肠道定植和疾病的前瞻性研究。
Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery.
作者信息
Privitera G, Scarpellini P, Ortisi G, Nicastro G, Nicolin R, de Lalla F
机构信息
Department of Biology, University of Lecce, Italy.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):208-10. doi: 10.1128/AAC.35.1.208.
Abstract
A total of 108 volunteers undergoing an elective surgical procedure were randomly given a single 2-g intravenous prophylactic dose of either a cephalosporin or mezlocillin. Stool samples were cultured for Clostridium difficile the day before the operation and later on postoperative days 4, 7, and 14. C. difficile was detected in 23.0% of patients who received a cephalosporin (cefoxitin, 8.3%; cefazolin, 14.3%; cefotetan, 20.0%; ceftriaxone, 25.0%; cefoperazone, 43.7%), in 3.3% of patients given mezlocillin, and in none of 15 control volunteers given no antimicrobial agent. No patient experienced diarrhea.
摘要
共有108名接受择期外科手术的志愿者被随机给予单次2克静脉预防性剂量的头孢菌素或美洛西林。在手术前一天以及术后第4、7和14天采集粪便样本培养艰难梭菌。在接受头孢菌素的患者中，23.0%检测到艰难梭菌（头孢西丁，8.3%；头孢唑林，14.3%；头孢替坦，20.0%；头孢曲松，25.0%；头孢哌酮，43.7%），接受美洛西林的患者中为3.3%，而15名未接受抗菌药物的对照志愿者中均未检测到。没有患者出现腹泻。
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