与胶原病相关的蛋白丢失性肠病。
Protein losing enteropathy associated with collagen diseases.
作者信息
Tsutsumi A, Sugiyama T, Matsumura R, Sueishi M, Takabayashi K, Koike T, Tomioka H, Yoshida S
机构信息
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
出版信息
Ann Rheum Dis. 1991 Mar;50(3):178-81. doi: 10.1136/ard.50.3.178.
Four patients with collagen diseases are described, who developed protein losing enteropathy in the course of their disease. Their protein losing enteropathies subsided after treatment with 60 mg/day oral prednisolone. Immunohistological studies of the small intestine showed deposits of C3 in the capillary walls of villi in two patients. Increased capillary permeability due to autoimmune phenomena may have a role in the pathogenesis of protein losing enteropathy associated with collagen diseases.
本文描述了4例胶原病患者，他们在病程中出现了蛋白丢失性肠病。口服泼尼松龙60mg/天治疗后，他们的蛋白丢失性肠病得到缓解。对小肠进行的免疫组织学研究显示，两名患者绒毛毛细血管壁有C3沉积。自身免疫现象导致的毛细血管通透性增加可能在胶原病相关蛋白丢失性肠病的发病机制中起作用。
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