Kovacs E J
Dept of Cell Biology, Neurobiology and Anatomy, Loyola University Stritch School of Medicine, Maywood, IL 60153.
Immunol Today. 1991 Jan;12(1):17-23. doi: 10.1016/0167-5699(91)90107-5.
A variety of diseases that are characterized by fibrosis share common features including the proliferation of fibroblasts and the deposition of extracellular matrix. Fibrosis often begins as an inflammatory reaction with leukocyte infiltration followed by the elaboration of cytokines. Here, Elizabeth J. Kovacs argues that the aberrant production of these mediators sustains the connective tissue accumulation that results in permanent alteration in tissue structure and function.
多种以纤维化为特征的疾病具有共同特征，包括成纤维细胞增殖和细胞外基质沉积。纤维化通常始于伴有白细胞浸润的炎症反应，随后是细胞因子的释放。在此，伊丽莎白·J·科瓦奇认为，这些介质的异常产生维持了结缔组织的积累，导致组织结构和功能的永久性改变。
