Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Clin Oral Investig. 2011 Apr;15(2):201-7. doi: 10.1007/s00784-010-0381-2. Epub 2010 Feb 12.
Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.
骨化性纤维瘤（COF）属于口腔骨相关病变。本研究旨在完善其组织学特征，并将肿瘤的组织病理学表现与临床行为相关联。分析了肿瘤基质中骨小球的数量、细胞密度、出血、炎症和软骨内骨化的存在情况，并与 10 例 COF 患者的主要症状相关联。所有患者均有肿胀，持续时间为 3 至 20 个月（平均 10.4 个月）。其他临床症状包括面部不对称、眼球突出和牙齿移位。下颌骨肿瘤的演变时间（12.3 个月）长于上颌骨（9.5 个月）。COF 的主要组织形态学诊断标准是砂粒体样结构。在病史较长的病变中，“砂粒体样”体的数量更多。在疾病病程较短的病变中，其数量较低，且存在基质出血和炎症。一名患者下颌骨的原发性 COF 中出现了动脉瘤样骨囊肿的继发性叠加。COF 的组织学表现可能受肿瘤演变的影响。已证明疾病临床病程与组织学参数之间存在显著相关性。
