来自缬草的具有细胞毒性的酰化环烯醚萜类化合物。
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
作者信息
Lin Sheng, Shen Yun-Heng, Li Hui-Liang, Yang Xian-Wen, Chen Tao, Lu Long-Hai, Huang Zheng-Sheng, Liu Run-Hui, Xu Xi-Ke, Zhang Wei-Dong, Wang Hui
机构信息
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
出版信息
J Nat Prod. 2009 Apr;72(4):650-5. doi: 10.1021/np800716f.
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.
从蜘蛛香（缬草属植物缬草的同义词）全草中分离得到13个新的酰化环烯醚萜类化合物，jatamanvaltrates A - M（1 - 13），以及9个已知的缬草三酯类化合物（14 - 22）。通过对光谱数据的详细解析确定了这些新化合物的结构。jatamanvaltrates D（4）和H（9）是天然存在的缬草三酯类化合物中首次在C - 10位含有邻羟基苯甲酰氧基部分的例子。对所有分离得到的化合物进行了针对肺腺癌（A549）、转移性前列腺癌（PC - 3M）、结肠癌（HCT - 8）和肝癌（Bel7402）细胞系的细胞毒性测试。
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