Lin Sheng, Shen Yun-Heng, Zhang Zhong-Xiao, Li Hui-Liang, Shan Lei, Liu Run-Hui, Xu Xi-Ke, Zhang Wei-Dong
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
J Nat Prod. 2010 Oct 22;73(10):1723-6. doi: 10.1021/np100426j. Epub 2010 Sep 20.
The structures of 1,5-dihydroxy-3,8-epoxyvalechlorine (1a) and volvaltrate B (6a), two new chlorinated iridoids isolated from Valeriana jatamansi and V. officinalis, respectively, were originally assigned on the basis of spectroscopic methods. Reinvestigation using X-ray analysis and chemical transformation revealed that the original assignment of H-7 in 1a and OH-8 in 6a should be inverted and that the structures should be revised to 1 and 6, respectively. Correspondingly, the structure of valeriotetrate C (7a) should be revised to 7. Volvaltrate B (6) showed cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 μM, respectively.
1,5 - 二羟基 - 3,8 - 环氧缬草氯酯（1a）和缬草环酯B（6a）分别是从印度缬草和缬草中分离得到的两种新的氯化环烯醚萜，其结构最初是根据光谱方法确定的。通过X射线分析和化学转化进行的重新研究表明，1a中H - 7和6a中OH - 8的原始归属应该颠倒，并且结构应分别修订为1和6。相应地，缬草四环酯C（7a）的结构应修订为7。缬草环酯B（6）对肺腺癌（A549）、转移性前列腺癌（PC - 3M）、结肠癌（HCT - 8）和肝癌（Bel7402）细胞系显示出细胞毒性活性，IC50值分别为8.5、2.0、3.2和6.1 μM。
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