Lin Sheng, Fu Peng, Chen Tao, Ye Ji, Yang Xian-Wen, Zhang Wei-Dong
a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
J Asian Nat Prod Res. 2017 Jan;19(1):15-21. doi: 10.1080/10286020.2016.1258065. Epub 2016 Dec 7.
Three new minor valepotriate isomers, jatamanvaltrates Z1 (1), Z2 (2), and Z3 (3), have been isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii.). Their structures were elucidated by extensive spectroscopic analysis, especially 2D NMR and ESI-MS/MS. All isolated compounds displayed moderate cytotoxicity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3 M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines with IC values of 2.8-8.3 μM.
从缬草（同义词：印度缬草）的全株中分离出三种新的小缬草素异构体，即缬草缬草素Z1（1）、Z2（2）和Z3（3）。通过广泛的光谱分析，尤其是二维核磁共振和电喷雾串联质谱，阐明了它们的结构。所有分离出的化合物对肺腺癌（A549）、转移性前列腺癌（PC-3 M）、结肠癌（HCT-8）和肝癌（Bel7402）细胞系均表现出中等细胞毒性，IC值为2.8 - 8.3 μM。
