南半球流感疫苗推荐评估。
Evaluation of Southern Hemisphere influenza vaccine recommendations.
机构信息
Fogarty International Center, National Institutes of Health, 16 Center Drive,MSC 6705, Building 16, Bethesda, MD 20892, United States.
出版信息
Vaccine. 2010 Mar 24;28(15):2693-9. doi: 10.1016/j.vaccine.2010.01.053. Epub 2010 Feb 11.
Abstract
In 1999, the World Health Organization switched from annual to semi-annual recommendations for influenza vaccine composition. We compared the antigenic match between recommendations and circulating viruses before and after 1999, in the Northern and Southern Hemispheres. Vaccine match proportion for A/H3N2 viruses increased from 31% to 59% in the Southern Hemisphere (P<0.05), and is now comparable to that in the Northern Hemisphere. Vaccine match for influenza B decreased from approximately 100% to 33-54% in both hemispheres (P<0.05), following the unexpected resurgence of influenza B/Victoria in 1997. No estimate was available for influenza A/H1N1. We conclude that semi-annual vaccine recommendations are useful overall and discuss potential ways forward, including a recommendation for the improvement of vaccination policy and influenza surveillance in tropical areas.
摘要
1999 年，世界卫生组织将流感疫苗成分的年度建议改为半年建议。我们比较了 1999 年前后南北半球建议与流行病毒之间的抗原匹配情况。南半球 A/H3N2 病毒的疫苗匹配比例从 31%增加到 59%（P<0.05），现在与北半球相当。1997 年乙型流感/Brisbane 病毒意外复活后，两个半球的乙型流感疫苗匹配比例从约 100%降至 33-54%（P<0.05）。对于甲型流感 H1N1，我们没有估计。我们的结论是，半年建议总体上是有用的，并讨论了前进的方向，包括改善疫苗接种政策和热带地区流感监测的建议。
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