Grupo de Inmunología y Epidemiología Molecular, GIEM, Facultad de Salud, Universidad Industrial de Santander, Colombia AA678.
Hum Pathol. 2010 Apr;41(4):610-3. doi: 10.1016/j.humpath.2009.11.005. Epub 2010 Feb 12.
The Trypanosoma cruzi taxon is composed of 2 major lineages, T cruzi I and T cruzi II. The clinical symptoms of Chagas disease are highly variable, and their geographic distribution is correlated with the distribution of the parasite lineages. In Colombia and northern South America, T cruzi I lineage is associated with chagasic cardiomyopathy. Alternatively, in the countries south cone of South America, there is a predominance of T cruzi II, which is associated with cardiomyopathy and digestive diseases. We report for the first time a mixed infection consisting of both T cruzi I and T cruzi II detected in the esophagus and in the heart, respectively, of a cardiomyopathic patient from an endemic area in Santander, Colombia. This finding has epidemiological relevance related to the association of T cruzi II with the clinical manifestations of Chagas disease and its frequency in Colombia and countries in northern South America.
克氏锥虫分类群由 2 个主要谱系组成，即 T cruzi I 和 T cruzi II。恰加斯病的临床症状差异很大，其地理分布与寄生虫谱系的分布相关。在哥伦比亚和南美洲北部，T cruzi I 谱系与克氏锥虫性心肌病相关。相反，在南美洲南部国家，T cruzi II 占主导地位，与心肌病和消化系统疾病相关。我们首次报道了一例来自哥伦比亚桑坦德地区的克氏锥虫性心肌病患者，在其食管和心脏中分别检测到了 T cruzi I 和 T cruzi II 的混合感染。这一发现具有流行病学意义，与 T cruzi II 与恰加斯病临床表现的关联及其在哥伦比亚和南美洲北部国家的频率有关。
