The University of Michigan, Ann Arbor, MI 48109-1290, USA.
J Addict Dis. 2009 Jul;28(3):232-42. doi: 10.1080/10550880903028452.
This secondary analysis of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) data examined the non-medical use of prescription analgesics and determined its relationship to continued non-medical use and substance use disorders 3 years later. Prospective data were collected using the Alcohol Use Disorders and Associated Disabilities Interview Schedule: DSM-IV Version (AUDADIS-DSM-IV). A nationally representative sample (n = 34,653) of U.S. adults 18 years or older were interviewed at Wave 1 (2001-2002) and re-interviewed at Wave 2 (2004-2005). Multivariate logistic regression analyses indicated younger age (18 to 24 years) and non-medical use at Wave 1 was associated with higher odds of a general substance or opioid use disorder at Wave 2 (adjusted odds ratio = 3.42, 95% confidence interval = 1.45, 8.07); however, most respondents who engaged in non-medical use will cease using 3 years later although non-medical use is associated with higher prevalence of a future substance use disorder.
这项对国家酒精和相关情况流行病学调查（NESARC）数据的二次分析检查了处方止痛药的非医疗用途，并确定了其与 3 年后继续非医疗使用和物质使用障碍的关系。前瞻性数据是使用酒精使用障碍和相关障碍访谈时间表：DSM-IV 版本（AUDADIS-DSM-IV）收集的。对年龄在 18 岁或以上的美国成年人进行了全国代表性抽样（n=34653），在第 1 波（2001-2002 年）进行了访谈，并在第 2 波（2004-2005 年）进行了重新访谈。多变量逻辑回归分析表明，第 1 波时年龄较小（18 至 24 岁）和非医疗使用与第 2 波时一般物质或阿片类药物使用障碍的几率较高相关（调整后的优势比=3.42，95%置信区间=1.45，8.07）；然而，尽管非医疗使用与未来物质使用障碍的更高患病率相关，但大多数从事非医疗使用的受访者将在 3 年后停止使用。
