Akdeniz University, Antalya, Turkey.
Nutr Cancer. 2009;61(6):784-8. doi: 10.1080/01635580903285171.
We conducted a study to investigate if lycopene could reduce gastrointestinal toxicity of abdominal and pelvic radiation in Wistar albino rats. Animals received either a control diet (Group 1), lycopene-supplemented diet (Group 2), control diet and radiation (Group 3), and lycopene-supplemented diet plus radiation (Group 4). In Groups 2 and 4, the rats received 5 mg/kg/day lycopene for 10 days. In Groups 3 and 4, the rats received single fraction 8 Gy abdominal and pelvic radiation (RT) on Day 10. Study endpoints included weight loss, diarrhea, duration of diarrhea, survival, and an oxidative stress marker, plasma level of thiobarbituric acid reactive substance (TBARS). The rats receiving RT only had significantly higher weight loss rate compared to the lycopene plus RT group (P = 0.001). Plasma TBARS levels after RT were also significantly higher in the RT only group compared to lycopene plus RT group (P = 0.001). In conclusion, lycopene supplementation significantly reduced the weight loss and prevented oxidative stress in rats treated with abdominopelvic radiation.
我们进行了一项研究，以探讨番茄红素是否可以减轻 Wistar 白化大鼠腹部和盆腔放射治疗的胃肠道毒性。动物分为对照组（第 1 组）、番茄红素补充组（第 2 组）、对照组加放射组（第 3 组）和番茄红素补充组加放射组（第 4 组）。第 2 组和第 4 组的大鼠每天接受 5 毫克/千克的番茄红素 10 天。第 3 组和第 4 组的大鼠在第 10 天接受单次 8Gy 的腹部和盆腔放射治疗（RT）。研究终点包括体重减轻、腹泻、腹泻持续时间、生存率和氧化应激标志物，即血浆硫代巴比妥酸反应物质（TBARS）水平。仅接受 RT 的大鼠与番茄红素加 RT 组相比，体重减轻率显著更高（P = 0.001）。仅接受 RT 的大鼠的血浆 TBARS 水平也明显高于番茄红素加 RT 组（P = 0.001）。总之，番茄红素补充剂可显著减轻接受腹盆部放射治疗的大鼠的体重减轻，并预防氧化应激。
