用中药靶向肿瘤蛋白酶体。
Targeting tumor proteasome with traditional Chinese medicine.
作者信息
Yang Huanjie, Liu Jinbao, Dou Q Ping
机构信息
The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
出版信息
Curr Drug Discov Technol. 2010 Mar;7(1):46-53. doi: 10.2174/157016310791162785.
Abstract
The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-kappaB pathway whose activation is dependent on the proteasome activity.
摘要
蛋白酶体是一种多催化蛋白酶复合体，其活性是正常细胞或肿瘤细胞生长所必需的。研究表明，人类癌细胞比正常细胞对蛋白酶体抑制更敏感，这表明蛋白酶体可能是化疗的一个靶点。研究表明，传统中药（TCM）是治疗癌症的一种有效方法。在这里，我们综述了几种中药在癌症治疗方面的潜力。这篇简短的综述主要关注那些可能靶向肿瘤细胞蛋白酶体和NF-κB通路的中药，NF-κB通路的激活依赖于蛋白酶体活性。
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