Division of Molecular Carcinogenesis and Targeted Therapy for Cancer, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Molecules. 2011 Jun 23;16(6):5283-97. doi: 10.3390/molecules16065283.
The thunder god vine or Tripterygium wilfordii Hook. F. is a representative Chinese medicinal herb which has been used widely and successfully for centuries in treating inflammatory diseases. More than 100 components have been isolated from this plant, and most of them have potent therapeutic efficacy for a variety of autoimmune and inflammatory diseases. In the past four decades, the anticancer activities of the extracts from this medicinal herb have attracted intensive attention by researchers worldwide. The diterpenoid epoxide triptolide and the quinone triterpene celastrol are two important bioactive ingredients that show a divergent therapeutic profile and can perturb multiple signal pathways. Both compounds promise to turn traditional medicines into modern drugs. In this review, we will mainly address the anticancer activities and mechanisms of action of these two agents and briefly describe some other antitumor components of the thunder god vine.
雷公藤或昆明山海棠是一种具有代表性的中药，几个世纪以来，它在治疗炎症性疾病方面得到了广泛而成功的应用。从这种植物中已经分离出 100 多种成分，其中大多数对多种自身免疫性和炎症性疾病具有很强的治疗效果。在过去的四十年中，这种草药提取物的抗癌活性引起了全世界研究人员的浓厚兴趣。二萜环氧三萜内酯雷公藤内酯和醌三萜类化合物土槿皮乙酸是两种重要的生物活性成分，它们表现出不同的治疗谱，可以干扰多种信号通路。这两种化合物有望使传统药物转化为现代药物。在这篇综述中，我们将主要介绍这两种药物的抗癌活性和作用机制，并简要描述雷公藤的其他一些抗肿瘤成分。
