Rouse B T, Grewal A S, Babiuk L A, Fujimiya Y
Infect Immun. 1977 Dec;18(3):660-5. doi: 10.1128/iai.18.3.660-665.1977.
An investigation was made of the effects of complement on the levels of antibody-dependence cytotoxicity (ADCC) mediated by bovine leukocytes against herpesvirus-infected target cells. Neutrophil-mediated ADCC was considerably enhanced upon the addition of low levels of complement that alone failed to induce lysis of antibody-sensitized target cells. This enhancement was most apparent under suboptimum conditions such as at low effector-to-target cell ratios, low levels of sensitizing antiserum, and short-duration assays. Furthermore, cells and classes of immunoglobulin unable to induce ADCC could do so in the presence of complement. The action of complement is considered in terms of a more tenacious bond formed between effector and target cells. The implications of the results are discussed in terms of the part that complement might play in enhancing antiviral recovery processes.
对补体对牛白细胞介导的针对疱疹病毒感染靶细胞的抗体依赖性细胞毒性（ADCC）水平的影响进行了研究。添加低水平的补体后，中性粒细胞介导的ADCC显著增强，而单独的补体未能诱导抗体致敏靶细胞的裂解。在次优条件下，如低效应细胞与靶细胞比例、低水平的致敏抗血清和短时间检测中，这种增强最为明显。此外，无法诱导ADCC的细胞和免疫球蛋白类别在有补体存在时也能诱导ADCC。补体的作用被认为是效应细胞与靶细胞之间形成了更强韧的结合。根据补体在增强抗病毒恢复过程中可能发挥的作用，对结果的意义进行了讨论。
