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同源结构域资源库:关于同源结构域蛋白家族的序列、结构、相互作用、基因组和功能信息的综合集合。

The Homeodomain Resource: a comprehensive collection of sequence, structure, interaction, genomic and functional information on the homeodomain protein family.

作者信息

Moreland R Travis, Ryan Joseph F, Pan Christopher, Baxevanis Andreas D

机构信息

Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Database (Oxford). 2009;2009:bap004. doi: 10.1093/database/bap004. Epub 2009 Apr 17.

Abstract

The Homeodomain Resource is a curated collection of sequence, structure, interaction, genomic and functional information on the homeodomain family. The current version builds upon previous versions by the addition of new, complete sets of homeodomain sequences from fully sequenced genomes, the expansion of existing curated homeodomain information and the improvement of data accessibility through better search tools and more complete data integration. This release contains 1534 full-length homeodomain-containing sequences, 93 experimentally derived homeodomain structures, 101 homeodomain protein-protein interactions, 107 homeodomain DNA-binding sites and 206 homeodomain proteins implicated in human genetic disorders.Database URL: The Homeodomain Resource is freely available and can be accessed at http://research.nhgri.nih.gov/homeodomain/

摘要

同源异型域资源库是一个精心整理的关于同源异型域家族的序列、结构、相互作用、基因组和功能信息的集合。当前版本在先前版本的基础上进行了更新,增加了来自全基因组测序的新的、完整的同源异型域序列集,扩展了现有的经过整理的同源异型域信息,并通过更好的搜索工具和更完整的数据整合提高了数据的可访问性。此版本包含1534个全长含同源异型域序列、93个通过实验获得的同源异型域结构、101个同源异型域蛋白-蛋白相互作用、107个同源异型域DNA结合位点以及206个与人类遗传疾病相关的同源异型域蛋白。数据库网址:同源异型域资源库可免费获取,网址为http://research.nhgri.nih.gov/homeodomain/

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