Mariño-Ramírez Leonardo, Hsu Benjamin, Baxevanis Andreas D, Landsman David
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894-6075, USA.
Proteins. 2006 Mar 1;62(4):838-42. doi: 10.1002/prot.20814.
The Histone Database is a curated and searchable collection of full-length sequences and structures of histones and nonhistone proteins containing histone-like folds, compiled from major public databases. Several new histone fold-containing proteins have been identified, including the huntingtin-interacting protein HYPM. Additionally, based on the recent crystal structure of the Son of Sevenless protein, an interpretation of the sequence analysis of the histone fold domain is presented. The database contains an updated collection of multiple sequence alignments for the four core histones (H2A, H2B, H3, and H4) and the linker histones (H1/H5) from a total of 975 organisms. The database also contains information on the human histone gene complement and provides links to three-dimensional structures of histone and histone fold-containing proteins. The Histone Database is a comprehensive bioinformatics resource for the study of structure and function of histones and histone fold-containing proteins. The database is available at http://research.nhgri.nih.gov/histones/.
组蛋白数据库是一个经过整理且可搜索的数据库，它收录了从主要公共数据库中汇编而来的组蛋白和含有组蛋白样折叠的非组蛋白的全长序列及结构。已鉴定出几种新的含组蛋白折叠的蛋白质，包括与亨廷顿蛋白相互作用的蛋白质HYPM。此外，基于最近七less之子蛋白的晶体结构，对组蛋白折叠结构域的序列分析进行了解读。该数据库包含了来自总共975种生物的四种核心组蛋白（H2A、H2B、H3和H4）以及连接组蛋白（H1/H5）的多序列比对的更新集合。该数据库还包含有关人类组蛋白基因互补的信息，并提供了组蛋白和含组蛋白折叠蛋白三维结构的链接。组蛋白数据库是用于研究组蛋白和含组蛋白折叠蛋白的结构与功能的综合生物信息学资源。该数据库可在http://research.nhgri.nih.gov/histones/获取。
