Laganà A, Forte S, Giudice A, Arena M R, Puglisi P L, Giugno R, Pulvirenti A, Shasha D, Ferro A
Department of Biomedical Sciences, University of Catania, Italy, 95124, Department of Mathematics and Computer Sciences, University of Catania, Catania, Italy, 95125 and Courant Institute of Mathematical Sciences, New York University, New York, USA, 10012-1185.
Database (Oxford). 2009;2009:bap008. doi: 10.1093/database/bap008. Epub 2009 Aug 4.
miRò is a web-based knowledge base that provides users with miRNA-phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into a unified database equipped with an intuitive and flexible query interface and data mining facilities. The main goal of miRò is the establishment of a knowledge base which allows non-trivial analysis through sophisticated mining techniques and the introduction of a new layer of associations between genes and phenotypes inferred based on miRNAs annotations. Furthermore, a specificity function applied to validated data highlights the most significant associations. The miRò web site is available at: http://ferrolab.dmi.unict.it/miro.Database URL:http://ferrolab.dmi.unict.it/miro.
miRò是一个基于网络的知识库，它为用户提供人类中miRNA与表型的关联信息。它将来自各种在线来源的数据，如miRNA数据库、本体、疾病和靶点数据库，整合到一个统一的数据库中，该数据库配备了直观且灵活的查询界面和数据挖掘工具。miRò的主要目标是建立一个知识库，通过复杂的挖掘技术进行深入分析，并引入基于miRNA注释推断的基因与表型之间的新关联层。此外，应用于验证数据的特异性函数突出了最显著的关联。miRò网站可访问：http://ferrolab.dmi.unict.it/miro。数据库网址：http://ferrolab.dmi.unict.it/miro。
