Vinogradova Irina A, Anisimov Vladimir N, Bukalev Andrey V, Semenchenko Anna V, Zabezhinski Mark A
Petrozavodsk State University, pr. Lenina, 33, Petrozavodsk 185910, Russia.
Aging (Albany NY). 2009 Oct 2;1(10):855-65. doi: 10.18632/aging.100092.
We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans.
我们评估了不同光暗周期对大鼠生存、寿命和肿瘤发生的影响。将208只雄性和203只雌性LIO大鼠分为4组,自25日龄起直至自然死亡,分别置于不同的光暗周期环境中:标准的12:12光暗周期(LD);俄罗斯西北部的自然光照(NL);持续光照(LL)和持续黑暗(DD)。我们发现,与标准的LD周期相比,暴露于NL和LL周期会加速代谢综合征的发展和自发肿瘤的发生,缩短雄性和雌性大鼠的寿命。我们得出结论,夜间光照引起的昼夜节律紊乱会加速大鼠衰老并促进肿瘤发生。这一观察结果支持了国际癌症研究机构的结论,即涉及昼夜节律紊乱的轮班工作可能对人类具有致癌性。