植物微管和细胞周期相关丝氨酸-苏氨酸蛋白激酶的生物信息学搜索。

Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

BMC Genomics. 2010 Feb 10;11 Suppl 1(Suppl 1):S14. doi: 10.1186/1471-2164-11-S1-S14.

A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

进行了生物信息学搜索，以寻找参与细胞分裂和微管蛋白磷酸化调节的人类丝氨酸-苏氨酸蛋白激酶的植物同源物（SLK、PAK6、PAK7、MARK1、MAST2、TTBK1、TTBK2、AURKA、PLK1、PLK4 和 PASK）。鉴定出了一些 SLK、MAST2 和 AURKA 的植物同源物。鉴定出的人类 AURKA 激酶最接近的同源物是一种未知功能的蛋白，来自葡萄（Vitis vinifera）的 A7PY12/GSVIVT00026259001（此处命名为“STALK”，丝氨酸-苏氨酸极光样激酶）。STALK 的三维结构分析证实了它与 AURKA 样蛋白激酶亚组的关系。