Suppr超能文献

龙葵和蓖麻提取物对组胺和角叉菜胶诱导的鸡皮肤炎症的影响。

Effect of Solanum nigrum and Ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin.

作者信息

Lomash V, Parihar S K, Jain N K, Katiyar A K

机构信息

Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Madhya Pradesh, India.

出版信息

Cell Mol Biol (Noisy-le-grand). 2010 Feb 9;56 Suppl:OL1239-51.

Abstract

We studied anti-inflammatory effect of ethanolic extract of Solanum nigrum leaves and Ricinus communis root bark using chicken skin as model. Leaves of these plants were dried under shade and powdered. 5% Ethanol extracts were prepared using Soxhlet and injected intraperitoneally (400 mg/kg) 1 hour prior to the induction of inflammation. Inflammatory lesion were induced by intradermal injection of 0.02 ml 0.05%w/v histamine (0-2 min, 15 min, 30 min, 1 hr and 6 hr) and 1% w/v carrageenan (0-2 min, 30 min, 1 hr, 6 hr, 12 hr and 48 hr) in different group of birds. Increase in vascular permeability was studied using Evans blue as a permeability marker both qualitatively and quantitatively. Cellular events were studied in skin lesions at various time intervals and cells were counted at high power objective under microscope. Both, extracts exhibited significant decrease in permeability response at an early stage (0-2 min) of histamine as well as in carrageenan induced inflammatory lesions. There was a significant (p< 0.05) suppression in the emigration of heterophils, monocytoid cells, basophils and total leukocytosis in Solanum nigrum and Ricinus communis pretreated chicken skin lesions as compared to the control. The present study suggested antihistamine and anti-inflammatory properties of ethanolic extract of Solanum nigrum and Ricinus communis.

摘要

我们以鸡皮为模型研究了龙葵叶乙醇提取物和蓖麻根皮的抗炎作用。将这些植物的叶子在阴凉处晾干并磨成粉末。使用索氏提取器制备5%乙醇提取物,并在诱导炎症前1小时腹腔注射(400mg/kg)。在不同组的鸡中,通过皮内注射0.02ml 0.05%w/v组胺(0 - 2分钟、15分钟、30分钟、1小时和6小时)和1%w/v角叉菜胶(0 - 2分钟、30分钟、1小时、6小时、12小时和48小时)诱导炎症损伤。使用伊文思蓝作为通透性标记物,定性和定量地研究血管通透性的增加。在不同时间间隔对皮肤损伤中的细胞事件进行研究,并在显微镜下高倍物镜下对细胞进行计数。两种提取物在组胺诱导的炎症损伤以及角叉菜胶诱导的炎症损伤的早期阶段(0 - 2分钟)均表现出通透性反应的显著降低。与对照组相比,在龙葵和蓖麻预处理的鸡皮肤损伤中,嗜异性粒细胞、单核样细胞、嗜碱性粒细胞的迁移以及总白细胞增多均受到显著(p<0.05)抑制。本研究表明龙葵和蓖麻乙醇提取物具有抗组胺和抗炎特性。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验