Infectious Disease Initiative, The Broad Institute, Cambridge, MA 02141, USA; Massachusetts General Hospital, Boston, MA 02114, USA.
Mol Cell. 2010 Feb 12;37(3):297-8. doi: 10.1016/j.molcel.2010.01.027.
In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, leading to an increase in mutation rate and the emergence of multidrug-resistant bacterial strains.
在本期《分子细胞》中，Kohanski 等人（2010）证明，即使亚抑菌浓度的杀菌抗生素也会导致活性氧的产生，从而导致突变率增加和多药耐药细菌株的出现。
