快速通往多重耐药之路。
The fast track to multidrug resistance.
机构信息
Infectious Disease Initiative, The Broad Institute, Cambridge, MA 02141, USA; Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Mol Cell. 2010 Feb 12;37(3):297-8. doi: 10.1016/j.molcel.2010.01.027.
PMID:20159549
Abstract
In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, leading to an increase in mutation rate and the emergence of multidrug-resistant bacterial strains.
摘要
在本期《分子细胞》中，Kohanski 等人（2010）证明，即使亚抑菌浓度的杀菌抗生素也会导致活性氧的产生，从而导致突变率增加和多药耐药细菌株的出现。
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