免疫系统在自闭症生物学中的作用。
The immune system's role in the biology of autism.
机构信息
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, California, USA.
出版信息
Curr Opin Neurol. 2010 Apr;23(2):111-7. doi: 10.1097/WCO.0b013e3283373514.
PURPOSE OF REVIEW
The following is a review of the most recent research concerning the potential role of immune system dysfunction in autism. This body of literature has expanded dramatically over the past few years as researchers continue to identify immune anomalies in individuals with autism.
RECENT FINDINGS
The most exciting of these recent findings is the discovery of autoantibodies targeting brain proteins in both children with autism and their mothers. In particular, circulating maternal autoantibodies directed toward fetal brain proteins are highly specific for autism. This finding has great potential as a biomarker for disease risk and may provide an avenue for future therapeutics and prevention. Additionally, data concerning the cellular immune system in children with autism suggest there may be a defect in signaling pathways that are shared by the immune and central nervous systems. Although studies to explore this hypothesis are ongoing, there is great interest in the commonalities between the neural and immune systems and their extensive interactions.
SUMMARY
In summary, the exciting research regarding the role of the immune system in autism spectrum disorders may have profound implications for diagnosis and treatment of this devastating disease.
目的综述
以下是对免疫系统功能障碍在自闭症中潜在作用的最新研究的综述。随着研究人员继续在自闭症患者中发现免疫异常，这方面的文献在过去几年中大幅增加。
最新发现
其中最令人兴奋的发现是在自闭症儿童及其母亲中发现了针对大脑蛋白的自身抗体。特别是，针对胎儿大脑蛋白的循环母体自身抗体对自闭症具有高度特异性。这一发现具有作为疾病风险生物标志物的巨大潜力，并可能为未来的治疗和预防提供途径。此外，关于自闭症儿童细胞免疫系统的数据表明，免疫和中枢神经系统共享的信号通路可能存在缺陷。尽管正在进行探索这一假设的研究，但人们对神经网络系统和免疫系统之间的共同性及其广泛的相互作用非常感兴趣。
总结
总之，关于免疫系统在自闭症谱系障碍中的作用的令人兴奋的研究可能对这种毁灭性疾病的诊断和治疗具有深远的影响。
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