Al-Salihy Adil Abdul-Rehman Siddiq
Mental Health Department, Psychological Research Center, Ministry of Higher Education & Scientific Research, Baghdad, Iraq.
Sci Rep. 2025 Apr 10;15(1):12207. doi: 10.1038/s41598-025-97313-8.
This study is the first to investigate potential correlations between blood groups, Rh factors, and Autism Spectrum Disorder (ASD) within a diverse dataset of 2,390 participants from multiple regions in Iraq. The participants included children with ASD, children with other neurodevelopmental disorders, typically developing children and their parents. Using chi-square tests, logistic regression analysis, and machine learning algorithms, the findings revealed that the O + blood group was the most prevalent across all groups. Importantly, logistic regression analysis identified the AB + blood group as being associated with a significantly lower risk of ASD, suggesting a novel protective factor. No significant associations were observed between other blood groups, Rh factors, and ASD risk. Additionally, the study found no statistically significant differences in blood group distributions among children with ASD, other neurodevelopmental disorders, and typically developing children. These results provide new insights into the potential immunogenetic contributions to ASD and emphasize the need for further research to confirm the protective effect of the AB + blood group. Such studies may help unravel the genetic, immunological, and environmental mechanisms underlying ASD and support the development of targeted diagnostic and preventative strategies.
本研究首次在来自伊拉克多个地区的2390名参与者的多样化数据集中，调查血型、Rh因子与自闭症谱系障碍（ASD）之间的潜在关联。参与者包括患有ASD的儿童、患有其他神经发育障碍的儿童、发育正常的儿童及其父母。通过卡方检验、逻辑回归分析和机器学习算法，研究结果显示，O+血型在所有组中最为普遍。重要的是，逻辑回归分析确定AB+血型与ASD风险显著降低相关，表明这是一个新的保护因素。在其他血型、Rh因子与ASD风险之间未观察到显著关联。此外，研究发现患有ASD的儿童、患有其他神经发育障碍的儿童和发育正常的儿童之间，血型分布没有统计学上的显著差异。这些结果为ASD潜在的免疫遗传学贡献提供了新的见解，并强调需要进一步研究以证实AB+血型的保护作用。此类研究可能有助于揭示ASD背后的遗传、免疫和环境机制，并支持制定有针对性的诊断和预防策略。
