Ruiz-Riera E, Vidal E, Canturri A, Lehmbecker A, Cuvertoret M, Lopez-Figueroa C, Baumgärtner W, Domingo M, Segalés J
Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Campus de la Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain.
Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain.
Animals (Basel). 2023 Jul 10;13(14):2255. doi: 10.3390/ani13142255.
The term wasting refers to a clinical sign used to describe a physical condition characterized by growth retardation, usually of multifactorial origin. The objective of the present study was to describe for the first time a pathological process characterized by forebrain neuropil vacuolization in pigs showing wasting without conspicuous neurological signs. To characterize the lesions pathologically, affected and non-affected pigs from eight of these farms were investigated. Histologically, the most consistent lesion was neuropil vacuolization of the prosencephalon, mainly located in the thalamic nuclei and in the transition between the white and grey matter of the neocortex (40/56 in sick and 4/30 in healthy pigs). In the most severe cases, the vacuolation also involved the midbrain, cerebellar nuclei and, to a lesser extent, the medulla oblongata. Vacuolization of the forebrain was associated with pigs experiencing marked emaciation and growth retardation. Although the specific cause of the present case remained unknown, the preventive use of multivitamin and mineral complexes in drinking water ameliorated the condition, strongly suggesting a metabolic origin of the observed condition.
消瘦这一术语指的是一种临床体征，用于描述通常由多因素引起的以生长发育迟缓为特征的身体状况。本研究的目的是首次描述一种病理过程，该过程以出现消瘦但无明显神经体征的猪的前脑神经纤维网空泡化为特征。为了从病理学上对病变进行特征描述，对来自其中8个农场的患病猪和未患病猪进行了调查。组织学上，最一致的病变是前脑的神经纤维网空泡化，主要位于丘脑核以及新皮质白质和灰质之间的过渡区域（患病猪56头中有40头，健康猪30头中有4头）。在最严重的病例中，空泡化还累及中脑、小脑核，延髓受累程度较轻。前脑空泡化与猪明显消瘦和生长发育迟缓有关。尽管本病例的具体病因尚不清楚，但在饮用水中预防性使用多种维生素和矿物质复合物改善了病情，强烈提示所观察到的状况源于代谢问题。
