用于超导量子干涉仪弛豫测量和磁针活检的磁铁矿纳米颗粒的表征
Characterization of magnetite nanoparticles for SQUID-relaxometry and magnetic needle biopsy.
作者信息
Adolphi Natalie L, Huber Dale L, Jaetao Jason E, Bryant Howard C, Lovato Debbie M, Fegan Danielle L, Venturini Eugene L, Monson Todd C, Tessier Trace E, Hathaway Helen J, Bergemann Christian, Larson Richard S, Flynn Edward R
机构信息
Senior Scientific, LLC, 11109 Country Club NE, Albuquerque, New Mexico 87111 USA.
出版信息
J Magn Magn Mater. 2009 May 1;321(10):1459-1464. doi: 10.1016/j.jmmm.2009.02.067.
Magnetite nanoparticles (Chemicell SiMAG-TCL) were characterized by SQUID-relaxometry, susceptometry, and TEM. The magnetization detected by SQUID-relaxometry was 0.33% of that detected by susceptometry, indicating that the sensitivity of SQUID-relaxometry could be significantly increased through improved control of nanoparticle size. The relaxometry data were analyzed by the moment superposition model (MSM) to determine the distribution of nanoparticle moments. Analysis of the binding of CD34-conjugated nanoparticles to U937 leukemia cells revealed 60,000 nanoparticles per cell, which were collected from whole blood using a prototype magnetic biopsy needle, with a capture efficiency of >65% from a 750 µl sample volume in 1 minute.
通过超导量子干涉仪弛豫测量法、磁化率测量法和透射电子显微镜对磁铁矿纳米颗粒（Chemicell SiMAG-TCL）进行了表征。超导量子干涉仪弛豫测量法检测到的磁化强度是磁化率测量法检测到的磁化强度的0.33%，这表明通过改进对纳米颗粒尺寸的控制，超导量子干涉仪弛豫测量法的灵敏度可以显著提高。通过矩叠加模型（MSM）分析弛豫测量数据，以确定纳米颗粒矩的分布。对CD34偶联纳米颗粒与U937白血病细胞结合的分析显示，每个细胞有60,000个纳米颗粒，这些纳米颗粒使用原型磁性活检针从全血中收集，在1分钟内从750微升样品体积中捕获效率大于65%。
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