尿蛋白的来源及其通过尿蛋白质组学分析以检测疾病生物标志物
Sources of Urinary Proteins and their Analysis by Urinary Proteomics for the Detection of Biomarkers of Disease.
作者信息
Julian Bruce A, Suzuki Hitoshi, Suzuki Yusuke, Tomino Yasuhiko, Spasovski Goce, Novak Jan
机构信息
University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Proteomics Clin Appl. 2009 Aug 26;3(9):1029-1043. doi: 10.1002/prca.200800243.
Abstract
Renal disorders account for a substantial fraction of the budget for health care in many countries. Proteinuria is a frequent manifestation in afflicted patients, but the origin of the proteins varies based on the nature of the disorder. The emerging field of urinary proteomics has the potential to replace kidney biopsy as the diagnostic procedure of choice for patients with some glomerular forms of renal disease. To fully realize this potential, it is vital to understand the basis for the urinary excretion of protein in physiological and pathological conditions. In this review, we discuss the structure of the nephron, the functional unit of the kidney, and the process by which proteins/peptides enter the urine. We discuss several aspects of proteinuria that impact the proteomic analysis of urine of patients with renal diseases.
摘要
在许多国家，肾脏疾病占医疗保健预算的很大一部分。蛋白尿是患病患者的常见表现，但蛋白质的来源因疾病性质而异。新兴的尿液蛋白质组学领域有可能取代肾活检，成为某些肾小球形式肾病患者的首选诊断程序。为了充分实现这一潜力，了解生理和病理条件下蛋白质尿排泄的基础至关重要。在这篇综述中，我们讨论了肾脏的功能单位肾单位的结构，以及蛋白质/肽进入尿液的过程。我们讨论了蛋白尿影响肾病患者尿液蛋白质组分析的几个方面。
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