Department of Otolaryngology-Head and Neck Surgery, Magna Graecia University of Catanzaro, Italy.
Acta Otorhinolaryngol Ital. 2009 Aug;29(4):187-90.
Toluidine blue stain is used as a marker to differentiate lesions at high risk of progression in order to improve early diagnosis of oropharyngeal carcinomas. This study focused on 45 oral mucosal lesions in 32 patients (13 female, 19 male). In 9 cases, multiple biopsies were collected. Of the 45 lesions examined, 26 (57.0%) were defined clinically benign, while 19 (42.3%) were defined as suspected lesions (premalignant or malignant). According to the clinical examination, the sensitivity was 53% (16/30) and for toluidine blue staining 96.2% (26/27) (p = 0.0007). The specificity was 80% (12/15) for clinical examination and 77.7% (14/15) for toluidine blue staining (p = 0.79). In conclusion toluidine blue stain has been shown to be a reliable aid when clinical examination is unable to differentiate lesions at high risk of progression and then it improves early diagnosis for oral cavity and oropharyngeal cancer.
甲苯胺蓝染色被用作标记物来区分有进展高风险的病变，以提高口咽癌的早期诊断率。本研究共纳入 32 名患者的 45 例口腔黏膜病变（13 名女性，19 名男性），其中 9 例患者采集了多处活检。在检查的 45 例病变中，26 例（57.0%）临床定义为良性病变，而 19 例（42.3%）被定义为疑似病变（癌前或恶性病变）。根据临床检查，敏感性为 53%（16/30），甲苯胺蓝染色的敏感性为 96.2%（26/27）（p=0.0007）。临床检查的特异性为 80%（12/15），甲苯胺蓝染色的特异性为 77.7%（14/15）（p=0.79）。总之，当临床检查无法区分有进展高风险的病变时，甲苯胺蓝染色被证明是一种可靠的辅助手段，从而提高了口腔和口咽癌的早期诊断率。
