Tanko Y, Magaji G M, Yerima M, Magaji R A, Mohammed A
Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria.
Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):141-6. doi: 10.4314/ajtcam.v5i2.31265.
The aqueous leaves extract of Ocimum gratissimum was investigated for anti-nociceptive and anti-inflammatory effects in mice and rats. The models used to study the effect on nociception are the acetic acid-induced abdominal constriction test, hot-plate method in mice. The anti-inflammatory effect was investigated employing the formalin-induced hind-paw oedema in rats. The extract caused a significant (p<0.05), dose-dependent inhibition of acetic acid-induced writhing and hot-plate method. The extract also exhibited anti-inflammatory effect which was significant (P<0.001) at all the three doses. The intraperitoneal LD(50) value of the extract was 1264.9 mg/kg body weight in mice. Preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins and flavonoids. The results suggest the extract contained pharmacologically active principles, and supports the local application of the plant in painful and inflammatory conditions.
对丁香罗勒水叶提取物在小鼠和大鼠体内的抗伤害感受及抗炎作用进行了研究。用于研究对伤害感受影响的模型有乙酸诱导的腹部收缩试验、小鼠热板法。采用福尔马林诱导大鼠后爪水肿来研究其抗炎作用。该提取物对乙酸诱导的扭体反应和热板法产生了显著（p<0.05）的剂量依赖性抑制。该提取物在所有三个剂量下均表现出显著（P<0.001）的抗炎作用。该提取物在小鼠体内的腹腔注射半数致死量（LD50）值为1264.9毫克/千克体重。初步植物化学筛选显示存在生物碱、皂苷、单宁和黄酮类化合物。结果表明该提取物含有药理活性成分，并支持该植物在疼痛和炎症病症中的局部应用。
