Tanko Y, Mohammed A, Okasha M A, Umar A H, Magaji R A
Department of Human Physiology, ABU, Zaria. yusuftanko @ yahoo.com
Afr J Tradit Complement Altern Med. 2008 Jan 22;5(2):209-12. doi: 10.4314/ajtcam.v5i2.31275.
The ethanol extracts of Syzygium aromaticum flower bud were tested for anti-nociceptive and anti-inflammatory effects in mice and Wistar rats which were carried out using acetic acid-induced abdominal contractions in mice and formalin-induced hind paw edema in Wistar rats. Three doses of the ethanol extract (50, 100, and 200 mg/kg body weight i.p.) were used for both studies. The extract had an LD(50) of 565.7 mg/kg body weight intraperitoneally in mice. The extracts produced significant effect (P<0.05) at all the three doses. Similarly, the anti-nociceptive activity produced significant effects (P<0.05) at all the three doses of the extract. The result supports the local use of the plant in painful and inflammatory conditions.
对丁香花芽的乙醇提取物在小鼠和Wistar大鼠中进行了抗伤害感受和抗炎作用测试，分别通过小鼠醋酸诱导的腹部收缩和Wistar大鼠福尔马林诱导的后爪水肿来进行。两项研究均使用了三种剂量的乙醇提取物（腹腔注射，50、100和200毫克/千克体重）。该提取物在小鼠腹腔内的半数致死量（LD50）为565.7毫克/千克体重。提取物在所有三种剂量下均产生显著效果（P<0.05）。同样，抗伤害感受活性在提取物的所有三种剂量下均产生显著效果（P<0.05）。结果支持该植物在疼痛和炎症病症中的局部应用。
