Rao Sadia Saleem, Najam Rahila
Department of Pharmacology, University of Karachi, Karachi, Pakistan.
J Intercult Ethnopharmacol. 2016 Apr 14;5(3):244-9. doi: 10.5455/jice.20160402120142. eCollection 2016 Jun-Aug.
Coconut water is a natural beverage that is a part of daily diet of many people. This study was designed to explore the anti-inflammatory activity of coconut water of different maturation stages (young and mature) with rat paw edema model of inflammation using plethysmometer.
For this study, albino rats were selected and divided into four equal groups (10 rats in each group). Group 1 was set as control and administered distilled water 1 ml orally; Groups 2 and 3 were treated with young and mature coconut water, respectively, at 4 ml/100 g dose orally. Group 4 was treated with the standard drug (ibuprofen) at 400 mg/70 kg. 0.1 ml of 1% w/v acetic acid was administered in the subplantar tissue of rat paw 30 min after oral treatments of groups. Plethysmometer was used to measure rat paw edema.
Results revealed that both coconut water possess significant anti-inflammatory activity (P < 0.001). In comparison to control, percent inhibition by young coconut water was 20.22%, 35.13%, 42.52%, and 36% at 1, 2, 3, and 4 h of acetic acid administration, respectively. However, maximum percent inhibition (42.52%) was observed in the second phase of the inflammatory process. On the other hand, percent inhibition by mature coconut water was 18.80%, 25.94%, 24.13%, and 18.66% at 1, 2, 3, and 4 h of acetic acid administration, respectively. However, maximum percent inhibition (25.94%) was observed in the first phase of the inflammatory process.
This study strongly suggests the use of young coconut water for potent anti-inflammatory effect and mature coconut water for moderate anti-inflammatory effect.
椰子水是一种天然饮品，为许多人日常饮食的一部分。本研究旨在通过体积描记器，利用大鼠足爪水肿炎症模型，探究不同成熟阶段（幼嫩和成熟）椰子水的抗炎活性。
本研究选用白化大鼠并将其分为四组（每组10只大鼠）。第1组设为对照组，口服1毫升蒸馏水；第2组和第3组分别以4毫升/100克的剂量口服幼嫩和成熟椰子水。第4组用标准药物（布洛芬）以400毫克/70千克进行治疗。在各实验组口服给药30分钟后，将0.1毫升1%重量/体积的醋酸注射到大鼠足爪的足底组织中。使用体积描记器测量大鼠足爪水肿情况。
结果显示，两种椰子水均具有显著的抗炎活性（P < 0.001）。与对照组相比，在注射醋酸后的1、2、3和4小时，幼嫩椰子水的抑制率分别为20.22%、35.13%、42.52%和36%。然而，在炎症过程的第二阶段观察到最大抑制率（42.52%）。另一方面，在注射醋酸后的1、2、3和4小时，成熟椰子水的抑制率分别为18.80%、25.94%、24.13%和18.66%。然而，在炎症过程的第一阶段观察到最大抑制率（25.94%）。
本研究有力地表明，幼嫩椰子水具有强效抗炎作用，而成熟椰子水具有中等抗炎作用。
