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纳米功能化氧化锆和硫酸钡颗粒作为骨水泥添加剂。

Nanofunctionalized zirconia and barium sulfate particles as bone cement additives.

机构信息

Division of Engineering and Department of Orthopaedics, Brown University, 184 Hope Street, Providence, RI 02912, USA.

出版信息

Int J Nanomedicine. 2010 Feb 2;5:1-11.

PMID:20161983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2819907/
Abstract

Zirconia (ZrO(2)) and barium sulfate (BaSO(4)) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO(2) micron particles, bone cements with unfunctionalized ZrO(2) nanoparticles, bone cements with ZrO(2) nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO(4) micron particles, bone cements with unfunctionalized BaSO(4) nanoparticles, and bone cements with BaSO(4) nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

摘要

氧化锆（ZrO(2)）和硫酸钡（BaSO(4)）颗粒在聚合过程中被引入到甲基丙烯酸甲酯单体（MMA）溶液中，与聚甲基丙烯酸甲酯（PMMA）珠一起，开发出以下新型骨水泥：未功能化 ZrO(2)微米颗粒骨水泥、未功能化 ZrO(2)纳米颗粒骨水泥、ZrO(2)纳米颗粒用 3-(三甲氧基硅基)丙基甲基丙烯酸酯（TMS）功能化的骨水泥、未功能化的 BaSO(4)微米颗粒骨水泥、未功能化的 BaSO(4)纳米颗粒骨水泥和 BaSO(4)纳米颗粒用 TMS 功能化的骨水泥。结果表明，与对照未改性骨水泥相比，在体外培养 4 小时后，含有 BaSO(4)陶瓷颗粒的骨水泥中的成骨细胞（骨形成细胞）密度更高。与未改性骨水泥相比，24 小时后，含有所有陶瓷颗粒的骨水泥中的成骨细胞密度也更高，特别是含有纳米功能化陶瓷颗粒的骨水泥。含有陶瓷颗粒的骨水泥表现出明显改变的机械性能；具体来说，在拉伸载荷下，普通骨水泥和含有未功能化陶瓷颗粒的骨水泥表现出脆性失效模式，而含有纳米功能化陶瓷颗粒的骨水泥表现出塑性失效模式。最后，所有含有陶瓷颗粒的骨水泥的放射阻射率都比未改性骨水泥高。总之，本研究的结果表明，在传统骨水泥中添加未功能化和 TMS 功能化的陶瓷纳米颗粒对骨科应用的性能有积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92a/2819907/e89771ef09f7/ijn-5-001f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f92a/2819907/2f4341aa2331/ijn-5-001f1.jpg
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J Biomech. 2009 May 29;42(8):1120-6. doi: 10.1016/j.jbiomech.2009.02.005. Epub 2009 Apr 2.
3
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4
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9
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10
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