猫爪藤的黄酮类化合物、抗炎活性及细胞毒性
Flavonoids, anti-inflammatory activity and cytotoxicity of Macfadyena unguis-cati L.
作者信息
Aboutabl E A, Hashem F A, Sleem A A, Maamoon A A
机构信息
Pharmacognosy Department., Faculty of Pharmacy, Cairo University, Egypt.
出版信息
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):18-26. doi: 10.4314/ajtcam.v5i1.31251.
Ethyl acetate and ethanol extracts of unflowering aerial part of Macfadyena unguis-cati L. (Fam. Bignoniaceae) were found to be rich in phenolic compounds. From ethyl acetate extract, six flavonoids were identified, 8, methoxy, acacetin, 7-O glucoside; 6, methoxy apigenin 7-O glucoside; 4'-O methyl scutellarin, 6-O apiosyl galactoside; acacetin, 7-O glucosyl, 8-C rhamnosyl, 3-O-alpha arabinofuranoside; 4'-methyl, 6- methoxy kaempferol, 7-O, 8-C diglucoside and vicenin II were isolated, while 6, methoxy, acacetin 7-O glucoside; and quercitrin were isolated from ethanol extract. These compounds were characterized and identified by their physicochemical and spectral data. The crude ethanol extract exhibited significant anti-inflammatory activity (80.47%) and moderate cytotoxic activity against lung cell line.
对猫爪藤（紫葳科）未开花地上部分的乙酸乙酯提取物和乙醇提取物进行研究，发现其富含酚类化合物。从乙酸乙酯提取物中鉴定出6种黄酮类化合物，分别为8 - 甲氧基金合欢素7 - O - 葡萄糖苷、6 - 甲氧基芹菜素7 - O - 葡萄糖苷、4'-O - 甲基野黄芩苷6 - O - 芹菜糖基半乳糖苷、金合欢素7 - O - 葡萄糖基8 - C - 鼠李糖苷、3 - O - α - 阿拉伯呋喃糖苷、4'-甲基 - 6 - 甲氧基山奈酚7 - O - 8 - C - 二葡萄糖苷和异荭草苷II；从乙醇提取物中分离出6 - 甲氧基金合欢素7 - O - 葡萄糖苷和槲皮苷。这些化合物通过其理化性质和光谱数据进行了表征和鉴定。粗乙醇提取物表现出显著的抗炎活性（80.47%），对肺癌细胞系具有中度细胞毒性活性。
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