阿拉伯胶树（金合欢属，豆科）对小鼠体内伯氏疟原虫抗疟活性的体内筛选。
In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice.
作者信息
Mutai Charles, Rukunga Geoffrey, Vagias Constatinos, Roussis Vassilios
机构信息
Kenya Medical Research Institute, P.O Box 548540-00200, Nairobi, Kenya.
出版信息
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):46-50.
Abstract
The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.
摘要
对从阿拉伯胶树茎皮中分离得到的总提取物和羽扇豆烷三萜类化合物，在雌性瑞士小鼠模型中针对伯氏疟原虫ANKA株进行了活性评估。对五种分离出的化合物和粗提物进行了抗疟活性评估，并使用盐酸奎宁作为阳性对照。在感染伯氏疟原虫的小鼠中，只有桦木醇和甲醇提取物产生了显著的抗疟活性。这项研究证明了阿拉伯胶树中存在生物活性剂。
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