Musa Y M, Haruna A K, Ilyas M, Yaro A H, Ahmadu A A, Usman H
Department of Basic Sciences, College of Agriculture Lafia, Nasarawa State-Nigeria.
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):92-6. doi: 10.4314/ajtcam.v5i1.31261.
Phytochemical screening was carried out on the ethylacetate portion of the ethanolic extract of the leaves of Pseudocedrella kotschyii and then evaluated for its analgesic (acetic acid-induced writhing) and anti-inflammatory (raw egg albumin-induced oedema) activities in mice and rats respectively. Phytochemical screening of the ethylacetate partition portion of ethanolic extract revealed the presence of flavonoids, glycosides and tannins as major chemical constituents. Alkaloids saponins, cardiac glycosides, steroids were not dictated in the extract. The ethylacetate extract (50 and 100 mg/kg i.p) exhibited significant activity (p<0.05) against acetic acid-induced writhing in a dose dependent manner. In the anti-inflammatory activity the ethylacetate extract (50 and 100 mg/kg i.p.) caused a slight effect against the raw egg albumin-induced oedema. The effect was however observed not to be dose dependent. All these effects were compared with standard drug piroxicam (20 mg/kg i.p.).
对柯氏拟雪松树叶乙醇提取物的乙酸乙酯部分进行了植物化学筛选，然后分别在小鼠和大鼠中评估其镇痛（乙酸诱导扭体）和抗炎（生蛋清诱导水肿）活性。乙醇提取物乙酸乙酯分离部分的植物化学筛选显示，黄酮类、糖苷和单宁是主要化学成分。提取物中未检测到生物碱、皂苷、强心苷和甾体。乙酸乙酯提取物（50和100mg/kg腹腔注射）对乙酸诱导的扭体呈剂量依赖性显著活性（p<0.05）。在抗炎活性方面，乙酸乙酯提取物（50和100mg/kg腹腔注射）对生蛋清诱导的水肿有轻微作用。然而，观察到该作用不具有剂量依赖性。所有这些作用均与标准药物吡罗昔康（20mg/kg腹腔注射）进行了比较。
