Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.
Lab Chip. 2010 Mar 7;10(5):548-52. doi: 10.1039/b924816a. Epub 2010 Jan 7.
A method for integrating porous polymer membranes such as polycarbonate, polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The use of 3-aminopropyltriethoxysilane as a chemical crosslinking agent was extended to integrate membranes with PDMS and glass microfluidic channels. A strong, irreversible bond between the membranes and microfluidic structure was achieved. The bonding strength in the APTES treated devices was significantly greater than in devices fabricated using either a PDMS "glue" or two-part epoxy bonding method. Evaluation of a filtering microdevice and the pore structure via SEM indicates the APTES conjugation does not significantly alter the membrane transport function and pore morphology.
描述了一种将多孔聚合物膜(如聚碳酸酯、聚醚砜和聚对苯二甲酸乙二醇酯)集成到微流控器件中的方法。将 3-氨丙基三乙氧基硅烷用作化学交联剂,以将膜与 PDMS 和玻璃微流控通道集成在一起。在膜和微流控结构之间实现了牢固的、不可逆的键合。在经过 APTES 处理的器件中,键合强度明显大于使用 PDMS“胶”或双组分环氧树脂键合方法制造的器件。通过 SEM 对过滤微器件和孔结构进行评估表明,APTES 缀合不会显著改变膜传输功能和孔形态。