Division of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, Box 534, SE-751 21, Uppsala, Sweden.
J Mater Sci Mater Med. 2010 May;21(5):1605-9. doi: 10.1007/s10856-010-4022-8. Epub 2010 Feb 17.
This study proves that a film of Strontianite (SrCO(3)) successfully can be formed on a bioactive surface of sodium titanate when exposed to a strontium acetate solution. This Strontianite film is believed to enable local release of strontium ions from implant surfaces and thus stimulate bone formation in vivo. Depending on the method, different types of films were achieved with different release rates of strontium ions, and the results points at the possibility to tailor the rate and amount of strontium that is to be released from the surface. Strontium has earlier been shown to be highly involved in the formation of new bone as it stimulates the replication of osteoblasts and decreases the activity of osteoclasts. The benefit of strontium has for example been proved in studies where the number of vertebral compression fractures in osteoporotic persons was drastically reduced in patients receiving therapeutical doses of strontium. Therefore, it is here suggested that the bone healing process around an implant may be improved if strontium is administered locally at the site of the implant. The films described in this paper were produced by a simple immersion process where alkali treated titanium was exposed to an aqueous solution containing strontium acetate. By heating the samples at different times during the process, different release rates of strontium ions were achieved when the samples were exposed to simulated body fluid. The strontium containing films also promoted precipitation of bone like apatite when exposed to a simulated body fluid.
本研究证明，锶碳酸根（SrCO(3)）薄膜可以在暴露于醋酸锶溶液中的钛酸钠生物活性表面上成功形成。这种锶碳酸根薄膜被认为能够从植入物表面局部释放锶离子，从而刺激体内骨形成。根据方法的不同，采用不同的方法可以获得具有不同锶离子释放率的不同类型的薄膜，并且结果表明有可能定制从表面释放的锶的速率和量。已经证明，锶在新骨形成中高度参与，因为它刺激成骨细胞的复制并降低破骨细胞的活性。例如，在接受治疗剂量的锶的骨质疏松症患者中，椎骨压缩性骨折的数量大大减少的研究中已经证明了锶的益处。因此，有人建议，如果在植入物部位局部给予锶，则可以改善植入物周围的骨愈合过程。本文中描述的薄膜是通过简单的浸渍工艺制备的，其中经过碱处理的钛暴露于含有醋酸锶的水溶液中。通过在处理过程中的不同时间加热样品，当将样品暴露于模拟体液时，可以实现不同的锶离子释放率。当暴露于模拟体液时，含锶的薄膜还促进了类骨质磷灰石的沉淀。
