Department of Psychology, University of Milano-Bicocca, Milan, Italy.
Dig Liver Dis. 2010 Oct;42(10):718-23. doi: 10.1016/j.dld.2010.01.004. Epub 2010 Feb 16.
The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality.
To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study.
A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36).
The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores.
We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients.
目前，原发性胆汁性肝硬化（PBC）患者生活质量的可用自评问卷（PBC-40）仅在英国人群中得到验证，但它缺乏对其维度的评估。
验证 PBC-40 的意大利语和日语版本，并通过验证性因子分析评估 PBC-40 的原始结构的维度。使用正向-反向翻译方法将 PBC-40 翻译成意大利语和日语，然后在一项大型多中心研究的框架内，在焦点小组中进行审查。
一项 290 例 PBC 患者（125 例意大利语和 165 例日语）的样本，使用两个先前验证过的针对 PBC 特异性（PBC-40）和一般生活质量（SF-36）的问卷进行了评估。
验证性模型未能充分拟合原始假设结构。主成分分析导致了一个七因素结构，排除了特征性较低负荷的 13 个项目；PBC-27 问卷是最终的工具。PBC-27 与 SF-36 评分的强烈相关性支持了其有效性。
我们在此提出了一种用于 PBC 的生活质量问卷的替代结构，即 PBC-27，它似乎能有效地检测 PBC 对意大利语和日语患者生活质量的影响。
