Bawri S, Ali S, Phukan C, Tayal B, Baruwa P
Post Graduate, Deptt. of Medicine, Gauhati Medical College, Guwahati, Assam.
Lung India. 2008 Jul;25(3):118-23. doi: 10.4103/0970-2113.44122.
To determine sputum conversion rate at monthly intervals of 1st, 2nd and 3rd month in new smear positive cases (cat-1) under treatment under RNTCP.
The study was conducted at DOTS Center, Gauhati Medical College and Hospital; Guwahati between July 2005 to June 2006.The study is a prospective study and consists of 100 cases of new smear positive pulmonary tuberculosis cases (category 1) irrespective of age and sex.
The age & sex distribution of 100 patients showed that majority of the patients (74%) belonged to 2nd, 3rd and 4th decades & 75% were males and 25% were female with male to female ratio 3:1 respectively. The chest x-ray of 100 Smear Positive patients shows that only 60 (60%) patients had x-ray evidence of pulmonary Koch. In the present study, sputum conversion i.e. from smear positive to smear negative at the end of the 1st month is 71%, at the end of 2nd month is 84% and at the end of 3rd month is 92%. SUMMARY #ENTITYSTARTX00026;
In conclusion, the overall sputum conversion rate under Directly Observed Treatment, Short Course (DOTS) chemotherapy in 100 sputum smear positive Pulmonary Tuberculosis in DOTS centre, Gauhati Medical College & Hospital was 92%.The chest x-ray evidence of pulmonary Koch in 100 patients is 60%.The sputum conversion at the end of 1st month is 71%, at the end of 2nd month it is 84% and at the end of 3rd month the same is 92%. In the present study, the infectivity decreases from the baseline with significant P value for sputum conversion of 3+, 2+ and 1+ sputum positivity. Directly Observed Treatment is an effective intervention for improving adherence to tuberculosis treatment programme in a resource-poor country. A significant decrease in conversion rate was observed with the initial high grade smear positive cases. More Prospective studies on larger number of patients are necessary to sub-stantiate our findings in this study.
确定在国家结核病控制规划（RNTCP）下接受治疗的新涂片阳性病例（1类）在第1、2和3个月每月的痰菌转阴率。
该研究于2005年7月至2006年6月在高哈蒂医学院和医院的直接观察短程治疗（DOTS）中心进行。该研究为前瞻性研究，包括100例新涂片阳性的肺结核病例（1类），不分年龄和性别。
100例患者的年龄和性别分布显示，大多数患者（74%）属于第二、第三和第四个十年，75%为男性，25%为女性，男女比例为3:1。100例涂片阳性患者的胸部X光检查显示，只有60例（60%）患者有肺部结核的X光证据。在本研究中，第1个月末痰菌转阴（即从涂片阳性转为涂片阴性）率为71%，第2个月末为84%，第3个月末为92%。
总之，在高哈蒂医学院和医院的DOTS中心，100例痰涂片阳性肺结核患者在直接观察短程治疗（DOTS）化疗下的总体痰菌转阴率为92%。100例患者中有肺部结核的X光证据的比例为60%。第1个月末痰菌转阴率为71%，第2个月末为84%，第3个月末为92%。在本研究中，传染性从基线水平下降，对于3+、2+和1+痰菌阳性的痰菌转阴具有显著的P值。在资源匮乏的国家，直接观察治疗是提高结核病治疗方案依从性的有效干预措施。最初涂片高阳性病例的转阴率有显著下降。需要对更多患者进行更多前瞻性研究来证实本研究中的发现。
