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从 Baccharis retusa DC.（菊科）的叶子中分离出一种抗利什曼原虫和抗锥虫的黄烷酮。

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).

机构信息

Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo-Campus Diadema, 09972-270, Diadema, São Paulo, Brazil.

出版信息

Parasitol Res. 2010 Apr;106(5):1245-8. doi: 10.1007/s00436-010-1771-8. Epub 2010 Feb 18.

DOI:10.1007/s00436-010-1771-8
PMID:20165875
Abstract

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.

摘要

在从巴西植物群中选择新的生物活性化合物的过程中，Baccharis retusa DC.（菊科）叶的粗甲醇提取物对利什曼原虫和克氏锥虫表现出潜在的活性。甲醇提取物的二氯甲烷相的色谱分离得到了大量的生物活性衍生物，其被鉴定为 5,6,7-三羟基-4'-甲氧基黄烷酮。该化合物的结构是基于光谱数据分析确定的，主要是核磁共振和质谱。

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