Centre for Material and Fibre Innovation, Deakin University, Geelong, Victoria, Australia.
Macromol Biosci. 2010 Jun 11;10(6):599-611. doi: 10.1002/mabi.200900358.
Silk fibroin is a useful protein polymer for biomaterials and tissue engineering. In this work, porogen leached scaffolds prepared from aqueous and HFIP silk solutions were reinforced through the addition of silk particles. This led to about 40 times increase in the specific compressive modulus and the yield strength of HFIP-based scaffolds. This increase in mechanical properties resulted from the high interfacial cohesion between the silk matrix and the reinforcing silk particles, due to partial solubility of the silk particles in HFIP. The porosity of scaffolds was reduced from approximately 90% (control) to approximately 75% for the HFIP systems containing 200% particle reinforcement, while maintaining pore interconnectivity. The presence of the particles slowed the enzymatic degradation of silk scaffolds.
丝素蛋白是一种用于生物材料和组织工程的有用蛋白质聚合物。在这项工作中，通过添加丝素颗粒增强了从水相和 HFIP 丝素溶液中提取的致孔剂支架。这使得 HFIP 基支架的比压缩模量和屈服强度增加了约 40 倍。这种机械性能的提高是由于丝素基质和增强丝素颗粒之间的高界面内聚性，这是由于丝素颗粒在 HFIP 中部分溶解所致。HFIP 体系中含有 200%颗粒增强剂的支架的孔隙率从约 90%（对照）降低到约 75%，同时保持孔的连通性。颗粒的存在减缓了丝素支架的酶降解。
