通过模拟自然加工过程制备用于功能化丝绸骨科器械的再生丝绸材料。
Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing.
作者信息
Li Chunmei, Hotz Blake, Ling Shengjie, Guo Jin, Haas Dylan S, Marelli Benedetto, Omenetto Fiorenzo, Lin Samuel J, Kaplan David L
机构信息
Department of Biomedical Engineering, Tufts University, 4 Colby St. Medford, MA 02155, USA.
Department of Biomedical Engineering, Tufts University, 4 Colby St. Medford, MA 02155, USA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue Cambridge, MA 02139, USA.
出版信息
Biomaterials. 2016 Dec;110:24-33. doi: 10.1016/j.biomaterials.2016.09.014. Epub 2016 Sep 20.
Silk fibers spun by silkworms and spiders exhibit exceptional mechanical properties with a unique combination of strength, extensibility and toughness. In contrast, the mechanical properties of regenerated silk materials can be tuned through control of the fabrication process. Here we introduce a biomimetic, all-aqueous process, to obtain bulk regenerated silk-based materials for the fabrication of functionalized orthopedic devices. The silk materials generated in the process replicate the nano-scale structure of natural silk fibers and possess excellent mechanical properties. The biomimetic materials demonstrate excellent machinability, providing a path towards the fabrication of a new family of resorbable orthopedic devices where organic solvents are avoided, thus allowing functionalization with bioactive molecules to promote bone remodeling and integration.
蚕和蜘蛛吐出的丝纤维展现出非凡的机械性能，具备强度、延展性和韧性的独特组合。相比之下，再生丝材料的机械性能可通过控制制造工艺来调节。在此，我们引入一种仿生全水相工艺，以获得用于制造功能化骨科器械的块状再生丝基材料。该工艺生成的丝材料复制了天然丝纤维的纳米级结构，并具有出色的机械性能。这些仿生材料展现出优异的可加工性，为制造新一代可吸收骨科器械开辟了道路，避免了使用有机溶剂，从而能够用生物活性分子进行功能化处理，以促进骨重塑和骨整合。
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