脂肪组织工程在软组织再生中的应用。
Adipose tissue engineering for soft tissue regeneration.
机构信息
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, USA.
出版信息
Tissue Eng Part B Rev. 2010 Aug;16(4):413-26. doi: 10.1089/ten.TEB.2009.0544.
Current treatment modalities for soft tissue defects caused by various pathologies and trauma include autologous grafting and commercially available fillers. However, these treatment methods present a number of challenges and limitations, such as donor-site morbidity and volume loss over time. As such, improved therapeutic modalities need to be developed. Tissue engineering techniques offer novel solutions to these problems through development of bioactive tissue constructs that can regenerate adipose tissue in both structure and function. Recently, a number of studies have been designed to explore various methods to engineer human adipose tissue. This review will focus on these developments in the area of adipose tissue engineering for soft tissue replacement. The physiology of adipose tissue and current surgical therapies used to replace lost tissue volume, specifically in breast tissue, are introduced, and current biomaterials, cell sources, and tissue culture strategies are discussed. We discuss future areas of study in adipose tissue engineering.
目前，针对各种病理和创伤引起的软组织缺损，治疗方法包括自体移植和市售填充剂。然而，这些治疗方法存在许多挑战和局限性，例如供区发病率和随时间推移的体积损失。因此，需要开发改良的治疗方法。组织工程技术通过开发具有生物活性的组织构建体，为解决这些问题提供了新的解决方案，这些构建体可以在结构和功能上再生脂肪组织。最近，许多研究旨在探索各种方法来构建人类脂肪组织。本综述将重点关注脂肪组织工程在软组织替代领域的这些进展。介绍了脂肪组织的生理学和目前用于替代丢失组织体积的手术疗法，特别是在乳房组织中，并讨论了当前的生物材料、细胞来源和组织培养策略。我们讨论了脂肪组织工程未来的研究领域。
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