脂肪组织再生：最新进展
Adipose tissue regeneration: a state of the art.
作者信息
Casadei Alessandro, Epis Roberta, Ferroni Letizia, Tocco Ilaria, Gardin Chiara, Bressan Eriberto, Sivolella Stefano, Vindigni Vincenzo, Pinton Paolo, Mucci Giuseppe, Zavan Barbara
机构信息
Casadei Clinic, Via Olimpia 9, Mestre, 30174 Venezia, Italy.
出版信息
J Biomed Biotechnol. 2012;2012:462543. doi: 10.1155/2012/462543. Epub 2012 Oct 3.
Abstract
Adipose tissue pathologies and defects have always represented a reconstructive challenge for plastic surgeons. In more recent years, several allogenic and alloplastic materials have been developed and used as fillers for soft tissue defects. However, their clinical use has been limited by further documented complications, such as foreign-body reactions potentially affecting function, degradation over time, and the risk for immunogenicity. Tissue-engineering strategies are thus being investigated to develop methods for generating adipose tissue. This paper will discuss the current state of the art in adipose tissue engineering techniques, exploring the biomaterials used, stem cells application, culture strategies, and current regulatory framework that are in use are here described and discussed.
摘要
脂肪组织病理学和缺损一直是整形外科医生面临的重建挑战。近年来，已经开发了几种同种异体和异质材料，并用作软组织缺损的填充剂。然而，它们的临床应用受到进一步记录的并发症的限制，例如可能影响功能的异物反应、随时间降解以及免疫原性风险。因此，正在研究组织工程策略以开发生成脂肪组织的方法。本文将讨论脂肪组织工程技术的当前技术水平，探讨所使用的生物材料、干细胞应用、培养策略，以及在此描述和讨论当前正在使用的监管框架。
相似文献
1
Adipose tissue regeneration: a state of the art.
J Biomed Biotechnol. 2012;2012:462543. doi: 10.1155/2012/462543. Epub 2012 Oct 3.
2
Adipose tissue engineering for soft tissue regeneration.
Tissue Eng Part B Rev. 2010 Aug;16(4):413-26. doi: 10.1089/ten.TEB.2009.0544.
3
Adipose tissue and the vascularization of biomaterials: Stem cells, microvascular fragments and nanofat-a review.
Cytotherapy. 2020 Aug;22(8):400-411. doi: 10.1016/j.jcyt.2020.03.433. Epub 2020 Jun 2.
4
Stem cells and adipose tissue engineering.
Biomaterials. 2006 Dec;27(36):6052-63. doi: 10.1016/j.biomaterials.2006.07.033. Epub 2006 Sep 14.
5
Stem cells from adipose tissue allow challenging new concepts for regenerative medicine.
Tissue Eng. 2007 Aug;13(8):1799-808. doi: 10.1089/ten.2006.0165.
6
Strategies for bioengineered scaffolds that support adipose stem cells in regenerative therapies.
Regen Med. 2016 Sep;11(6):589-99. doi: 10.2217/rme-2016-0064. Epub 2016 Aug 3.
7
The potential of adipose-derived stem cells in craniofacial repair and regeneration.
Birth Defects Res C Embryo Today. 2012 Mar;96(1):95-7. doi: 10.1002/bdrc.21001.
8
Adipogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds.
Methods Mol Biol. 2011;702:319-30. doi: 10.1007/978-1-61737-960-4_23.
9
Soft tissue fillers for adipose tissue regeneration: From hydrogel development toward clinical applications.
Acta Biomater. 2017 Nov;63:37-49. doi: 10.1016/j.actbio.2017.09.026. Epub 2017 Sep 20.
10
Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.
Rom J Morphol Embryol. 2013;54(4):919-24.
引用本文的文献
1
Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering.
Heliyon. 2024 Jun 25;10(13):e33542. doi: 10.1016/j.heliyon.2024.e33542. eCollection 2024 Jul 15.
2
Highly Concentrated Stabilized Hybrid Complexes of Hyaluronic Acid: Rheological and Biological Assessment of Compatibility with Adipose Tissue and Derived Stromal Cells towards Regenerative Medicine.
Int J Mol Sci. 2024 Feb 7;25(4):2019. doi: 10.3390/ijms25042019.
3
Development of new bioabsorbable implants with de novo adipogenesis.
Regen Ther. 2023 Aug 12;24:311-317. doi: 10.1016/j.reth.2023.07.008. eCollection 2023 Dec.
4
Hybrid Stromal Vascular Fraction (Hybrid-SVF): A New Paradigm in Mechanical Regenerative Cell Processing.
Plast Reconstr Surg Glob Open. 2022 Dec 30;10(12):e4702. doi: 10.1097/GOX.0000000000004702. eCollection 2022 Dec.
5
Effects of Intra-Articular Autologous Adipose Micrograft for the Treatment of Osteoarthritis in Dogs: A Prospective, Randomized, Controlled Study.
Animals (Basel). 2022 Jul 20;12(14):1844. doi: 10.3390/ani12141844.
6
The Regeneration of Large-Sized and Vascularized Adipose Tissue Using a Tailored Elastic Scaffold and dECM Hydrogels.
Int J Mol Sci. 2021 Nov 22;22(22):12560. doi: 10.3390/ijms222212560.
7
A Feasibility Study on 3D Bioprinting of Microfat Constructs Towards Wound Healing Applications.
Front Bioeng Biotechnol. 2021 Jul 27;9:707098. doi: 10.3389/fbioe.2021.707098. eCollection 2021.
8
Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration.
Ann Med Surg (Lond). 2021 Jun 9;67:102482. doi: 10.1016/j.amsu.2021.102482. eCollection 2021 Jul.
9
Hyaluronic Acid: Redefining Its Role.
Cells. 2020 Jul 21;9(7):1743. doi: 10.3390/cells9071743.
10
The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds.
Stem Cells Int. 2020 Jan 9;2020:7056261. doi: 10.1155/2020/7056261. eCollection 2020.
本文引用的文献
1
Adipose Derived Regenerative Cell Therapy for Treating a Diabetic Wound: A Case Report.
Wounds. 2012 Jan;24(1):e1-5.
2
Effect of high glucose on extensive culturing of mesenchymal stem cells derived from subcutaneous fat, omentum fat and bone marrow.
Cell Biochem Funct. 2013 Jan;31(1):20-9. doi: 10.1002/cbf.2851. Epub 2012 Jun 25.
3
The insulin-like growth factors in adipogenesis and obesity.
Endocrinol Metab Clin North Am. 2012 Jun;41(2):283-95, v-vi. doi: 10.1016/j.ecl.2012.04.011.
4
Injectable biomaterials for adipose tissue engineering.
Biomed Mater. 2012 Apr;7(2):024104. doi: 10.1088/1748-6041/7/2/024104. Epub 2012 Mar 29.
5
Long-term in-vivo tumorigenic assessment of human culture-expanded adipose stromal/stem cells.
Exp Cell Res. 2012 Feb 15;318(4):416-23. doi: 10.1016/j.yexcr.2011.12.002. Epub 2011 Dec 13.
6
Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth.
Cell Cycle. 2011 Sep 15;10(18):3198-207. doi: 10.4161/cc.10.18.17638.
7
Immune response to human embryonic stem cell-derived cardiac progenitors and adipose-derived stromal cells.
J Cell Mol Med. 2012 Jul;16(7):1544-52. doi: 10.1111/j.1582-4934.2011.01435.x.
8
Immunological aspects of allogeneic and autologous mesenchymal stem cell therapies.
Hum Gene Ther. 2011 Dec;22(12):1587-91. doi: 10.1089/hum.2011.039. Epub 2011 Aug 10.
9
Immune responses to implants - a review of the implications for the design of immunomodulatory biomaterials.
Biomaterials. 2011 Oct;32(28):6692-709. doi: 10.1016/j.biomaterials.2011.05.078. Epub 2011 Jun 28.
10
Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer.
J Biol Chem. 2011 Jul 15;286(28):25007-15. doi: 10.1074/jbc.M110.213108. Epub 2011 May 18.
Zotero 插件