Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30345, USA.
Curr Opin Pharmacol. 2010 Apr;10(2):203-7. doi: 10.1016/j.coph.2010.01.006. Epub 2010 Feb 17.
Recent studies have shown that both innate and adaptive immunity contribute to hypertension. Inflammatory cells, including macrophages and T cells accumulate in the vessel wall, particularly in the perivascular fat, and in the kidney of hypertensive animals. Mice lacking lymphocytes are resistant to the development of hypertension, and adoptive transfer of T cells restores hypertensive responses to angiotensin II and DOCA-salt challenge. Immune modulating agents have variable, but often-beneficial effects in ameliorating end-organ damage and blood pressure elevation in experimental hypertension. The mechanisms by which hypertension stimulates an immune response remain unclear, but might involve the formation of neoantigens that activate adaptive immunity. Identification of these neoantigens and understanding how they form might prove useful in the prevention and treatment of this widespread and devastating disease.
最近的研究表明，先天免疫和适应性免疫都有助于高血压的发生。炎症细胞，包括巨噬细胞和 T 细胞，在血管壁中积聚，特别是在血管周围脂肪中和高血压动物的肾脏中。缺乏淋巴细胞的小鼠对高血压的发展具有抗性，并且 T 细胞的过继转移恢复了高血压动物对血管紧张素 II 和 DOCA-盐挑战的反应。免疫调节剂在改善实验性高血压中的靶器官损伤和血压升高方面具有不同但通常有益的作用。高血压刺激免疫反应的机制尚不清楚，但可能涉及激活适应性免疫的新抗原的形成。鉴定这些新抗原并了解它们如何形成可能对预防和治疗这种广泛而严重的疾病有用。
