Exercise Physiology Laboratory, Texas Christian University, Fort Worth, Texas, USA.
J Strength Cond Res. 2011 Jun;25(6):1529-37. doi: 10.1519/JSC.0b013e3182176638.
Regular exercise lowers indicators of disease risk including some inflammatory cytokines; however, the relationship between different modes of acute exercise, cytokine levels, and subsequent glucose tolerance is unclear. The purpose was to determine the effects of resistance (RES) and aerobic (AER) exercises on interleukin-6 (IL-6) and its association with glucose tolerance 24 hours after exercise. After testing for 1 repetition maximum (1RM) and VO2peak, 10 obese (body mass index > 30 kg · m(-2)), untrained men aged 18-26 years completed 3 protocols: 60 minutes of RES, AER, and a resting (CON) condition. The RES was 2 sets of 8 repetitions and a third set to fatigue at 80% 1RM of 8 lifts using all major muscle groups. The AER was 60 minutes of cycling at 70% of VO2peak. On day 1, subjects completed the 60-minute exercise or resting protocol, and on day 2, they completed an oral glucose tolerance test (OGTT). Blood was collected before and after exercise, at 2 and 7 hour postexercise, and before and every 30 minutes during the OGTT and was analyzed for IL-6, glucose and insulin. Postexercise IL-6 was greater in RES (8.01 ± 2.08 pg · mL(-1)) vs. in AER (4.26 ± 0.27 pg · mL(-1)), and both were greater than in CON (1.61 ± 0.18 pg · mL(-1)). During the OGTT, there were no differences in glucose or insulin between conditions for single time points or as area under the curve. The RES caused greater IL-6 levels immediately after exercise that may be related to the greater active muscle mass compared to AER. Neither exercise produced enhanced glucose removal compared to control; thus, despite the greater elevation in IL-6 in RES, for these exercise conditions and this population, this cytokine did not influence glucose tolerance.
定期运动可降低疾病风险指标，包括某些炎性细胞因子；然而，不同急性运动方式、细胞因子水平与随后的葡萄糖耐量之间的关系尚不清楚。本研究目的是确定抗阻运动（RES）和有氧运动（AER）对白细胞介素-6（IL-6）的影响及其与运动后 24 小时葡萄糖耐量的关系。在测试 1 次重复最大值（1RM）和最大摄氧量（VO2peak）后，10 名肥胖（体质量指数>30kg·m(-2))、未经训练的 18-26 岁男性完成了 3 项方案：60 分钟 RES、AER 和休息（CON）条件。RES 为 2 组 8 次重复，第 3 组重复至疲劳，使用所有主要肌群 8 次重复，重复次数为 80%1RM。AER 为 70%VO2peak 的 60 分钟自行车运动。第 1 天，受试者完成 60 分钟运动或休息方案，第 2 天，完成口服葡萄糖耐量试验（OGTT）。运动前后、运动后 2 和 7 小时以及 OGTT 期间每隔 30 分钟采集血液，分析白细胞介素-6、葡萄糖和胰岛素。RES 后运动后白细胞介素-6（8.01±2.08pg·mL(-1))高于 AER（4.26±0.27pg·mL(-1)))，均高于 CON（1.61±0.18pg·mL(-1)))。在 OGTT 中，在单一时间点或曲线下面积方面，条件之间的葡萄糖或胰岛素均无差异。RES 引起的运动后即刻白细胞介素-6水平更高，这可能与 RES 与 AER 相比，主动肌质量更大有关。与对照组相比，两种运动都没有增强葡萄糖的清除率；因此，尽管 RES 中的白细胞介素-6升高幅度更大，但对于这些运动条件和人群，这种细胞因子并没有影响葡萄糖耐量。
