弥漫性肺泡出血为表现的肺结核 1 例：抗心磷脂抗体是否起作用？

A case of pulmonary tuberculosis presenting as diffuse alveolar haemorrhage: is there a role for anticardiolipin antibodies?

机构信息

Respiratory Endoscopy Unit, National Institute for Infectious Diseases "L, Spallanzani", Via Portuense 292, 00149 Rome, Italy.

出版信息

BMC Infect Dis. 2010 Feb 20;10:33. doi: 10.1186/1471-2334-10-33.

DOI:10.1186/1471-2334-10-33

PMID:20170532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2831900/

Abstract

BACKGROUND

Diffuse alveolar haemorrhage (DAH) has been rarely reported in association with pulmonary infections.

CASE PRESENTATION

We report the case of a 43 year old immunocompetent man presenting with dyspnoea, fever and haemoptysis. Chest imaging showed bilateral ground glass opacities. Microbiological and molecular tests were positive for Mycobacterium tuberculosis and treatment with isoniazid, rifampicin, ethambutol and pyrazinamide was successful. In this case the diagnosis of DAH relies on clinical, radiological and endoscopic findings. Routine blood tests documented the presence of anticardiolipin antibodies. In the reported case the diagnostic criteria of antiphospholipid syndrome were not fulfilled.

CONCLUSIONS

The transient presence of anticardiolipin antibodies in association with an unusual clinical presentation of pulmonary tuberculosis is intriguing although a causal relationship cannot be established.

摘要

背景

弥漫性肺泡出血（DAH）与肺部感染相关的情况很少见。

病例介绍

我们报告了一例 43 岁免疫功能正常的男性患者，出现呼吸困难、发热和咯血。胸部影像学显示双侧磨玻璃影。微生物学和分子检测均为结核分枝杆菌阳性，异烟肼、利福平、乙胺丁醇和吡嗪酰胺治疗成功。在这种情况下，弥漫性肺泡出血的诊断依赖于临床、影像学和内镜检查结果。常规血液检查发现存在抗心磷脂抗体。在报告的病例中，抗磷脂综合征的诊断标准未得到满足。